Piperazine hexahydrate

Chinese Name:Piperazine Hexahydrate

Chinese Aliases: Piperazine (hexahydrate); Diethylenediamine (hexahydrate); Piperazine hexahydrate; 1,4-Diazacyclohexane (hexahydrate); Diethylenediamine (hexahydrate); Tetramethyldiamine (hexahydrate)

English Name:Piperazine hexahydrate

English Aliases:Piperazine hyexahydrate; Piperazine hydrate

CAS:142-63-2

EINECS:203-808-3

Molecular Formula:C₄H₂₂N₂O₆

Molecular Weight:194.2273

Piperazine hexahydrate, also known as 1,4-diazacyclohexane, is a colorless crystal with an ammonia-like odor and strong hygroscopicity. It is soluble in water, methanol, and ethanol, and slightly soluble in benzene.

Piperazine hexahydrate is produced from chloroethanol through amination and cyclization. The process involves heating chloroethanol and ammonium hydroxide in an autoclave until the ammonia pressure reaches 441 kPa, stirring for 5 hours, and recovering excess ammonium hydroxide at atmospheric pressure to obtain an aminoethanol aqueous solution. A measured amount of hydrochloric acid is added with stirring, and the mixture is concentrated under reduced pressure to a semi-paste-like ethanolamine hydrochloride concentrate. The temperature is raised to remove water until 150°C, pre-melted paraffin is added, and the temperature is further increased to 260°C, maintaining a reaction at (260±2)°C for 12 hours. The mixture is discharged and filtered to remove paraffin, yielding piperazine hydrochloride. Piperazine hydrochloride, solid sodium hydroxide, and water are added to a reaction kettle, stirred for 1.5 hours, and ammonia is expelled. The temperature is then raised to 130-140°C to distill off the piperazine hexahydrate solution. The residue is filtered out, and the piperazine hexahydrate solution is cooled to 8°C and centrifuged to obtain piperazine hexahydrate.

Preparation Method:

Using chloroethanol as the raw material, it is produced through amination and cyclization. The process involves heating chloroethanol and ammonium hydroxide in an autoclave until the ammonia pressure reaches 441 kPa, stirring for 5 hours, and recovering excess ammonium hydroxide at atmospheric pressure to obtain an aminoethanol aqueous solution. A measured amount of hydrochloric acid is added with stirring, and the mixture is concentrated under reduced pressure to a semi-paste-like ethanolamine hydrochloride concentrate. The temperature is raised to remove water until 150°C, pre-melted paraffin is added, and the temperature is further increased to 260°C, maintaining a reaction at (260±2)°C for 12 hours. The mixture is discharged and filtered to remove paraffin, yielding piperazine hydrochloride. Piperazine hydrochloride, solid sodium hydroxide, and water are added to a reaction kettle, stirred for 1.5 hours, and ammonia is expelled. The temperature is then raised to 130-140°C to distill off the piperazine hexahydrate solution. The residue is filtered out, and the piperazine hexahydrate solution is cooled to 8°C and centrifuged to obtain piperazine hexahydrate.

Physical and Chemical Properties: White crystals. Melting point: 41-45°C, Boiling range: 123-125°C

Chemical Properties: Combustible when exposed to open flame or high heat. Decomposes upon combustion, releasing toxic nitrogen oxide gases. Decomposes when heated, releasing toxic gases. Corrosive.

Uses: Piperazine hexahydrate is soluble in ethanol. Adding glacial acetic acid with stirring and cooling precipitates piperazine acetate, which is used in the synthesis of hormonal drugs such as hydrocortisone phosphate sodium. Piperazine hexahydrate reacts with acetic anhydride to produce acetylpiperazine, an intermediate for the anthelmintic drug piperazine nitrothiazole. Dehydration of piperazine hexahydrate yields anhydrous piperazine.

Piperazine Hexahydrate Firefighting Measures

Hazardous combustion products: Carbon monoxide, carbon dioxide, nitrogen oxides.

Fire extinguishing methods: Firefighters must wear anti-poison masks and full-body firefighting clothing, and fight the fire from the upwind direction.

Extinguishing agents: Water mist, foam, dry powder, carbon dioxide, sand.

Piperazine Hexahydrate Precautions:  (1) This product has low toxicity, but large doses may cause dizziness, headache, nausea, vomiting, etc. A few cases may develop urticaria, fatigue, gastrointestinal dysfunction, ataxia, and other reactions. (2) Contraindicated in patients with liver or kidney dysfunction, neurological disorders, or a history of epilepsy. (3) Laxatives may be added for constipated patients.

Piperazine Hexahydrate Hazard Characteristics: Combustible when exposed to open flame or high heat. Decomposes upon combustion, releasing toxic nitrogen oxide gases. Decomposes when heated, releasing toxic gases. Corrosive.

Piperazine Hexahydrate Main Uses:  Used in the manufacture of resins and polymers, and in pharmaceuticals.

Main Components: Pure product
Appearance and Properties: Colorless crystals with an ammonia-like odor, highly hygroscopic.
Melting Point (°C): 109.6
Boiling Point (°C): 148.5
Saturated Vapor Pressure (kPa):  30.3/111°C
Flash Point (°C):  107 (O.C)
Solubility: Soluble in water, methanol, ethanol; slightly soluble in benzene.

Piperazine Hexahydrate: Chinese Aliases: Diethylenediamine (hexahydrate); Piperazine hexahydrate; Piperazine Hexahydrate. Physical and chemical properties of piperazine hexahydrate: White crystals. Melting point: 41-45°C. Uses of piperazine hexahydrate: Used in pharmaceuticals and the synthesis of organic compounds. Changzhou Mingshun Chemical is a professional supplier of piperazine hexahydrate and other chemical raw materials, offering high-quality piperazine hexahydrate year-round at favorable prices, with现货供应.

Properties: Colorless crystals, melting point 44-45°C, boiling point 125-130°C. Easily soluble in water, soluble in ethanol. The pH of a 10% aqueous solution is 10.8-11.8.

Changzhou Mingshun Chemical specializes in the production of piperazine hexahydrate, anhydrous piperazine, and the piperazine series products. We supply high-quality piperazine hexahydrate year-round at favorable prices, with a complete range of chemical varieties. Piperazine Hexahydrate: Chinese Aliases: Diethylenediamine (hexahydrate); Piperazine hexahydrate; Piperazine Hexahydrate. Physical and chemical properties of piperazine hexahydrate: White crystals. Melting point: 41-45°C. Uses of piperazine hexahydrate: Used in pharmaceuticals and the synthesis of organic compounds.

Functions and Uses of Piperazine Hexahydrate: Pharmaceutical intermediate. Piperazine hexahydrate is mainly used in the production of anthelmintic drugs such as piperazine phosphate and piperazine citrate, as well as fluphenazine, strong pain relief, rifampicin. Piperazine hexahydrate is soluble in ethanol. Adding glacial acetic acid with stirring and cooling precipitates piperazine acetate, which is used in the synthesis of hormonal drugs such as hydrocortisone phosphate sodium. Piperazine hexahydrate reacts with acetic anhydride to produce acetylpiperazine, an intermediate for the anthelmintic drug piperazine nitrothiazole. Changzhou Mingshun Chemical is a professional supplier of piperazine hexahydrate and other chemical raw materials, offering high-quality piperazine hexahydrate year-round at favorable prices, with现货供应.